![]() The lab isolated cells at different stages of the cell cycle and performed RNA sequencing analyses to identify lncRNAs that were differentially expressed during specific cell cycle stages. In a collaborative effort, the researchers identified lncRNAs that exhibited differential expression, similar to protein-coding genes, during cell cycle. While the human genome encodes lncRNA genes, not much is known about their functions. However, the role of long noncoding RNAs (lncRNAs) in cell cycle progression has not been studied as thoroughly. Because, mutations in the cell cycle have such harmful effects, proteins responsible for cell cycle regulation are heavily researched. Deviations from the cycle lead to aberrant cell growth, which is linked to cancer. The cell cycle is a tightly regulated process. ![]() In a new article published in eLife, “The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway,” Prasanth and fellow researchers detail the role of long noncoding RNAs in cell cycle progression. Prasanth, professor of cell and developmental biology, and members of his lab investigate the regulation of gene expression and RNA biology with a focus on cancer. ![]() ![]() The graduate students who performed many of the experiments for this eLife paper during the COVID-19 pandemic. ![]()
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